Inhibitory Effects of n-Hexane Extracts of <i>Sida acuta</i> and <i>Aspilia africana</i> Leaves on Platelet Aggregation

http://www.doi.org/10.26538/tjpps/v3i1.3

Authors

  • Chukwudoruo C. Sunday Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri, Nigeria
  • Esonu E. Chimdi Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri, Nigeria.
  • Onuoha H. Chinyere Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri, Nigeria.
  • Osuagwu L. Olachi Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri, Nigeria.
  • Nwaekpe G. Chinweuba Department of Biochemistry, School of Biological Sciences, Federal University of Technology Owerri, Nigeria.

Keywords:

Inhibitory, Aspirin, aggregation, platelet, Aspilia africana, Sida acuta

Abstract

Platelet hyperactivity significantly contributes to the pathogenesis of arterial thrombosis and atherosclerosis. The primary objective of this investigation was to assess the antiplatelet activity of the n-Hexane leaf extract of Sida acuta and Aspilia africana leaves using in vitro experiment. Standard analytical procedures were employed using UV-Vis spectrophotometric method. Three concentrations (0.5mg/ml, 2mg/ml and 4mg/ml) of Sida acuta and Aspilia africana leaf extracts were utilised. Aspirin (2mg/ml) and distilled water serving as positive and negative controls, respectively. Platelet aggregation was induced using 10% w/v Calcium chloride. The findings demonstrated that the n-Hexane leaf extract of Sida acuta exhibited a statistically significant antiplatelet activity of 55.00 ± 0.46, 55.45 ± 0.91 and 55.30 ± 0.95 while Aspilia africana extract displayed antiplatelet activities of 47.64±0.65, 51.41±1.13, and 51.74±0.29 at concentrations of 0.5mg/ml, 2.0mg/ml, and 4.0mg/ml, respectively, surpassing the antiplatelet activity of Aspirin, which was measured at 39.83%. The findings suggest that the extracts of the leaves of Sida acuta and Aspilia africana possess significant antiplatelet activity.

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Published

2024-02-05

How to Cite

Sunday, C. C., Chimdi, E. E., Chinyere, O. H., Olachi, O. L., & Chinweuba, N. G. (2024). Inhibitory Effects of n-Hexane Extracts of <i>Sida acuta</i> and <i>Aspilia africana</i> Leaves on Platelet Aggregation: http://www.doi.org/10.26538/tjpps/v3i1.3. Tropical Journal of Phytochemistry and Pharmaceutical Sciences, 3(1), 131–135. Retrieved from https://www.tjpps.org/index.php/home/article/view/37